New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid.
By Eun-Kyung Kim, C. Park, W. Chung, K. Oh, Dong Ik Kim, Jong Tae Lee, H. Yoo. AJR. American journal of roentgenology, 2002
1,097 citations recorded by the source corpus.
OBJECTIVE The purpose of our study was to provide new sonographic criteria for fine-needle aspiration biopsy of nonpalpable solid thyroid nodules. MATERIALS AND METHODS Sonographic scans of 155 nonpalpable thyroid nodules in 132 patients were prospectively classified as having positive or negative findings. Sonographic findings that suggested malignancy included microcalcifications, an irregular or microlobulated margin, marked hypoechogenicity, and a shape that was more tall than it was wide. If even one of these sonographic features was present, the nodule was classified as positive (malignant). If a nodule had none of the features described, it was classified as negative (benign). The final diagnosis of a lesion as benign (n = 106) or malignant (n = 49) was confirmed by fine-needle aspiration biopsy and follow-up (>6 months) in 83 benign nodules, by fine-needle aspiration biopsy and surgery in 44 malignant and 15 benign lesions, and by surgery alone in five malignant and eight benign lesions. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated on the basis of our proposed classification method. RESULTS Of 82 lesions classified as positive, 46 were malignant. Of 73 lesions classified as negative, three were malignant. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy based on our sonographic classification method were 93.8%, 66%, 56.1%, 95.9%, and 74.8%, respectively. CONCLUSION Considering the high level of sensitivity of our proposed sonographic classification, fine-needle aspiration biopsy should be performed on thyroid nodules classified as positive, regardless of palpability.
Subfields: Endocrinology, Diabetes and Metabolism, Surgery
View Paper: https://www.semanticscholar.org/paper/686cd6fc682725e8d6215c22e7462d66d532f75a
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Citations in the corpus
- Applications of machine learning and deep learning to thyroid imaging: where do we stand? (2020, methodology): “US-based risk-stratification systems (RSS) have been used for the effective management of thyroid nodules since the early 2000s [17].”
- Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations (2016, background): “The nonparallel orientation presents the same US feature as the taller-than-wide shape defined previously (11, 33).”
- Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. (2006, result): “are consistent with prior studies (23, 24, 26, 28, 30).”