KAP1 controls endogenous retroviruses in embryonic stem cells
By Helen M. Rowe, Johan Jakobsson, D. Mesnard, Jacques Rougemont, Sévérine Reynard, Tuğçe Aktaş, P. Maillard, Hillary Layard-Liesching, Sonia Verp, Julien Marquis and 3 more. Nature, 2010
783 citations recorded by the source corpus.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/6825cb15238591088fc44d5296c5863426fc67dd
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In Molecular Biology
- Wolf Reik
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- Felix Krueger
- Fátima Santos
- Simon R. Andrews
- Julia Arand
- Johan Jakobsson
In Plant Science
Citations in the corpus
- KRAB zinc finger proteins (2017, background): “At sequences derived from TEs, this allows for the taming of transcriptional influences that would otherwise hamper early development, from zygotic genome activation to the establishment and normal differentiation of pluripotent stem cells (Rowe et al., 2010; Matsui et al., 2010; Rowe et al., 2013; ”
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family (2012, neutral): “TRIM28 Tripartite motif-containing 28 KAP1, RNF96, TIF1b Transcriptional regulator N Q13263 (Rowe et al., 2010)”
- The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, background): “5, are not transcribed at that stage, suggesting that other mechanisms for transcriptional repression of retrotransposons are in place, such as those provided by Setdb1 and Kap1 in ESCs (Rowe et al., 2010; Karimi et al., 2011).”
- Conservation of transcription factor binding specificities across 600 million years of bilateria evolution (2015, background): “…events that have occurred after separation of the invertebrate and vertebrate lineages have generally not lead to emergence of novel TF specificities, outside of the rapidly evolving human zinc finger proteins that suppress endogenous retroviruses (Rowe et al., 2010; Lukic et al., 2014).”
- In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions (2011, background): “Imprinted genes were deregulated in kap1 / ES cells, but these cells exhibit massive transcriptional changes, probably as a consequence of the functional inactivation of the more than 200 different KRAB-ZFPs expressed in this setting (Rowe et al., 2010) (and data not shown).”
- The Human Transcription Factors. (2018, neutral): “In human, KRAB C2H2-ZF proteins generally bind transposable elements (TEs) (mainly LINEs and endogenous retroviruses), presumably silencing them, at least initially, via the repressive function of the KRABdomain (Imbeault et al., 2017; Jacobs et al., 2014; Rowe et al., 2010; Schmitges et al., 2016).”