3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

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Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “For example, the level of bound sulfane sulfur in cells expressing MST and CAT is about twofold higher than in the cells which express a defective mutant of MST, of which an active center cysteine 247 is replaced to serine and does not produce H2S (426, 558).”
Hydrogen sulfide: a versatile regulator of environmental stress in plants (2015, background): “H 2 S is also produced by CAT and 3-MST from L-cysteine in the presence of a-ketoglutarate (Shibuya et al. 2009).”
Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure (2017, positive): “However, when in the presence of high levels of homocysteine, the γ -replacement between two molecules of homocysteine becomes the most dominant reaction for the H 2 S generation (71): The last H 2 S generating pathway is mediated by the synergism of aspartate aminotransferase (AAT) or CAT and 3-MST”
Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria (2010, neutral): “It is probably because CBS is localized to the cytosol of astrocytes, and it may be less efficient to produce H2S than 3MST with CAT in neurons or neural cells (48).”