Identification and Specification of the Mouse Skeletal Stem Cell
By Charles K. F. Chan, E. Seo, James Y Chen, D. Lo, A. McArdle, Rahul Sinha, R. Tevlin, J. Seita, Justin Vincent-Tompkins, Taylor L. Wearda and 13 more. Cell, 2015
684 citations recorded by the source corpus.
Summary How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage and stromal development from a population of highly pure, post-natal skeletal stem cells (mouse Skeletal Stem Cell, mSSC) to its downstream progenitors of bone, cartilage and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs in situ, even in non-skeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation towards bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues.
Subfields: Genetics, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/67d7508fb5cffad9047d23e19cb4965fdd60f472
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Citations in the corpus
- Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells Current stage and future perspectives (2018, neutral): “Currently, in vivo studies in rodents are starting to confirm the existence of a structured hierarchy of skeletal progenitor cells [181, 182].”
- The roles of vascular endothelial growth factor in bone repair and regeneration (2016, background): “This is consistent with findings that inhibition of VEGF signaling by sFlt1 promoted chondrogenesis of transplanted fetal skeletal tissues at the expense of osteogenesis [73].”
- Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration (2017, methodology): “, Acan, Col2a1, and Sox9), as well as previously described skeletal stem cell markers (Itga5 and CD200), at elevated levels (Figure 6E; Table S5) (Chan et al., 2015).”