Vital signs: overdoses of prescription opioid pain relievers---United States, 1999--2008.

By L. Paulozzi, Christopher M. Jones, K. Mack, R. A. Rudd. MMWR. Morbidity and mortality weekly report, 2011

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The Economic Burden of Prescription Opioid Overdose, Abuse and Dependence in the United States, 2013 (2016, background): “The adverse health effects of the misuse of prescription opioids, including abuse, dependence, and overdose are a well-documented public health problem.(1) Fatal prescription drug overdoses have been described as an epidemic by the US Centers for Disease Control and Prevention.”
Increases in Drug and Opioid Overdose Deaths—United States, 2000–2014 (2016, background): “Historically, CDC has programmatically characterized all opioid pain reliever deaths (natural and semisynthetic opioids, methadone, and other synthetic opioids) as “prescription” opioid overdoses (1).”
Increases in Drug and Opioid Overdose Deaths--United States, 2000-2014. (2016, background): “Opioid pain reliever prescribing has quadrupled since 1999 and has increased in parallel with overdoses involving the most commonly used opioid pain relievers (1).”