A Brief Review of Short Tandem Repeat Mutation
By Hao Fan, J. Chu. Genomics, Proteomics & Bioinformatics, 2007
316 citations recorded by the source corpus.
Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6798ff32c73471dcd825066a302ae110b65efcde
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- Variable tandem repeats accelerate evolution of coding and regulatory sequences. (2010, background): “Details of both mechanisms have been covered elsewhere (28, 98, 103, 118, 126).”