Preclinical research: Make mouse studies work

By S. Perrin. Nature, 2014

600 citations recorded by the source corpus.

Subfields: Aging, Computational Theory and Mathematics, Small Animals

View Paper: https://www.semanticscholar.org/paper/678aaa79d500be7b0c99d21819089255dea97bee

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1. Cynthia Hajal
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6. Yoojin Shin

Citations in the corpus

• An open investigation of the reproducibility of cancer biology research (2014, unknown): “…of appropriate controls, lack of equipment calibration, or unrecognized experimental variables ( Ioannidis, 2005 ; Nieuwenhuis et al., 2011 ; Loscalzo, 2012 ; Haibe-Kains et al., 2013 ; Pusztai et al., 2013 ; Vasilevsky et al., 2013 ; Hines et al., 2014 ; Ioannidis et al., 2014 ; Perrin, 2014 ).”
• 3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Although these techniques are considered the gold standard, 80% of successful drug candidates in animal models later failed in clinical trials [14,15].”
• Reproducibility in Science: Improving the Standard for Basic and Preclinical Research (2015, unknown): “…(2012)2 Oncology 90% of 53 studies were not reproduced Nekrutenko & Taylor(2012)25 NGS data access 26/50 no access to primary data sets/software Perrin (2014)26 Mouse, in-vivo 0/100 reported treatments repeated positive in studies of ALS Tsilidis et al (2013)27 Neurological studies Too many…”