Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis
By Elizabeth A. Reddy, Andrea V. Shaw, J. Crump. Lancet. Infectious Diseases (Print), 2010
651 citations recorded by the source corpus.
Data on the prevalence and causes of community-acquired bloodstream infections in Africa are scarce. We searched three databases for studies that prospectively studied patients admitted to hospital with at least a blood culture, and found 22 eligible studies describing 58 296 patients, of whom 2051 (13.5%) of 15 166 adults and 3527 (8.2%) of 43 130 children had bloodstream infections. 1643 (29.1%) non-malaria bloodstream infections were due to Salmonella enterica (58.4% of these non-typhoidal Salmonella), the most prevalent isolate overall and in adults, and 1031 (18.3% overall) were due to Streptococcus pneumoniae, the most common isolate in children. Other common isolates included Staphylococcus aureus (531 infections; 9.5%) and Escherichia coli (412; 7.3%). Mycobacterium tuberculosis complex accounted for 166 (30.7%) of 539 isolates in seven studies that used mycobacterial culture techniques. HIV infection was associated with any bloodstream infection, particularly with S enterica and M tuberculosis complex bacteraemia. Where recorded, patients with bloodstream infections had an in-hospital case fatality of 18.1%. Our results show that bloodstream infections are common and associated with high mortality. Improved clinical microbiology services and reassessment of empirical treatment guidelines that account for the epidemiology of bloodstream infections might contribute to better outcomes.
Subfields: Infectious Diseases, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/67414972800f153885cc5554069cc882b0262dc7
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- J. Crump
Citations in the corpus
- Evaluation of In-Hospital Management for Febrile Illness in Northern Tanzania before and after 2010 World Health Organization Guidelines for the Treatment of Malaria (2014, background): “Inpatients with fever are often empirically treated with antimalarials, leaving bacterial infections undiagnosed and untreated [3,6,7].”
- Diabetes in Sub Saharan Africa 1999-2011: Epidemiology and public health implications. a systematic review (2011, background): “[ 12-17 ]. With this double burden of disease and limited resources, diabetes must compete for political attention and financial investment.”