Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units

By Feng Song, Ping-bo Chen, Dapeng Sun, Mingzhu Wang, Liping Dong, Dan Liang, R. Xu, P. Zhu, Guohong Li. 2014

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In Molecular Biology

Citations in the corpus

Single-Particle Cryo-EM at Crystallographic Resolution. (2015, background): “…assemblies or complexes, such as clathrin coats (Fotin et al., 2004), the 26S proteasome (da Fonseca et al., 2012; Lander et al., 2012; Lasker et al., 2012), the anaphase promoting complex (Chang et al., 2014; da Fonseca et al., 2011), and chromatin fibers (Song et al., 2014), to name just a few.”
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. (2017, background): “Conceivably, the discrepancy may be due to differences in sample preparation (e.g., the use of a cross-linking reagent in the study by Song et al., 2014).”
Organization of Chromatin by Intrinsic and Regulated Phase Separation (2019, background): “Thus, 10n+5 linker length spacing disfavors the two-start helical arrangements found in 30 nm-like structures (Bass et al., 2019; Nikitina et al., 2017; Schalch et al., 2005; Song et al., 2014), suggesting that a different molecular association might arise from the linker lengths preferred in cells.”
Local states of chromatin compaction at transcription start sites control transcription levels (2021, methodology): “Using cryo-electron microscopy experiments, a similar compaction of in vitro-reconstituted chromatin by recombinant H1 was observed (68).”
Mapping nucleosome resolution chromosome folding in yeast by Micro-C (2015, unknown): “The structure of a 30 nm fiber is hotly debated, with major models being solenoid and zigzag paths of the beads-on-astring (Dorigo et al., 2004; Ghirlando and Felsenfeld, 2008; Routh et al., 2008; Song et al., 2014; Tremethick, 2007), as well as more recent polymorphic fiber models that incorporate ”