Hyaluronic acid (hyaluronan): a review

By J. Nečas, L. Bartošíková, P. Brauner, J. Kolar. 2018

733 citations recorded by the source corpus.

Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including humans. It is found in most connective tissues and is particularly concentrated in synovial fluid, the vitreous fluid of the eye, umbilical cords and chicken combs. It is naturally synthesized by a class of integral membrane protein s called hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases. This review describes metabolisms, different physi - ological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid.

Subfields: Cell Biology, Genetics, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/671a0a85c65b6b9f1eee7a18d10d29e11b24767b

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Citations in the corpus

• Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory (2019, background): “HA has excellent viscoelasticity, high moisture retention capacity, high biocompatibility, and hygroscopic properties (16, 26).”