Mechanism of action of sodium hypochlorite.

By Carlos Estrela, C. Estrela, E. Barbin, J. Spanó, M. Marchesan, J. PÉcora. Brazilian Dental Journal, 2002

733 citations recorded by the source corpus.

The choice of an irrigating solution for use in infected root canals requires previous knowledge of the microorganisms responsible for the infectious process as well as the properties of different irrigating solutions. Complex internal anatomy, host defenses and microorganism virulence are important factors in the treatment of teeth with asymptomatic apical periodontitis. Irrigating solutions must have expressive antimicrobial action and tissue dissolution capacity. Sodium hypochlorite is the most used irrigating solution in endodontics, because its mechanism of action causes biosynthetic alterations in cellular metabolism and phospholipid destruction, formation of chloramines that interfere in cellular metabolism, oxidative action with irreversible enzymatic inactivation in bacteria, and lipid and fatty acid degradation. The aim of this work is to discuss the mechanism of action of sodium hypochlorite based on its antimicrobial and physico-chemical properties.

Subfields: Oral Surgery

View Paper: https://www.semanticscholar.org/paper/671348cc2d843192a1465e7f18a3550dca09f8b5

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Citations in the corpus

• AVMA Guidelines for the euthanasia of animals (2013, positive): “18 SODIUM HYPOCHLORITE Sodium hypochlorite (bleach) and solutions made from calcium hypochlorite granules act as solvents and oxidants in tissue, resulting in saponification of fatty acids, denaturation of proteins, and derangement of cellular processes.(326) Hypochlorite has been used to euthanize ”