Apoptotic cell clearance: basic biology and therapeutic potential

By I. Poon, Christopher D. Lucas, A. Rossi, K. Ravichandran. Nature reviews. Immunology, 2014

1,133 citations recorded by the source corpus.

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and uptake, and the subsequent biological responses, are increasingly better defined. The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as immunological tolerance. Consequently, defects in apoptotic cell clearance have been linked with various inflammatory diseases and autoimmunity. Conversely, under certain conditions, such as the killing of tumour cells by specific cell-death inducers, the recognition of apoptotic tumour cells can promote an immunogenic response and antitumour immunity. Here, we review the current understanding of the complex process of apoptotic cell clearance in physiology and pathology, and discuss how this knowledge could be harnessed for new therapeutic strategies.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/66d84bbc1f6fdf10130525bd467cf62312da5859

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Citations in the corpus

Macrophage defense mechanisms against intracellular bacteria (2015, background): “These ligands are recognized by phagocytes promoting efferocytosis (131, 132).”
Mesenchymal stromal cells: clinical challenges and therapeutic opportunities (2018, background): “inherent biases in studying the immune physiology of interspecies cell transfer, these data speak to the possibility that MSCs may elicit a non-specific immune suppressive effect through their phagocytosis by the host reticuloendothelial system(Poon et al., 2014).”
Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration (2015, background): “In this regulatory network, cell cycle arrest and apoptosis are mechanisms or phenotypes that maintain homeostasis of organs [127] or ways to evade metastasis.”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “Apoptotic cells undergo a series of distinct changes, such as chromatin condensation, internucleosomal DNA fragmentation, nuclear rupture, mitochondrial swelling and cytochrome c release, proteolytic cleavage of the cytoskeleton and focal adhesion complexes, PS externalization, PM blebbing, disrupti”
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel (2020, background): “tosis, is an important homeostatic process that ensures resolution of inflammatory responses (Figure 4).(155,156) This involves recognition of”