Bispecific antibodies: a mechanistic review of the pipeline

By A. Labrijn, M. Janmaat, J. Reichert, P. Parren. Nature reviews. Drug discovery, 2019

1,094 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/66870e14af7dbc6c114298c22110633c4fd677a2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. I. Liu
2. Ruei-Min Lu
3. Yu-Chyi Hwang
4. Chi-Chiu Lee
5. Han‐Chung Wu
6. Hsin-Jung Li
7. Han-zen Tsai

Citations in the corpus

• Development of therapeutic antibodies for the treatment of diseases (2020, background): “The concepts and platforms driving the development of bispecific antibodies continue to advance rapidly, creating many new opportunities to make major therapeutic breakthroughs.”
• Modular repeat protein sculpting using rigid helical junctions (2020, neutral): “In contrast to traditional approaches to joining domains with flexible linkers and bispecific antibodies, with the flexible hinge between the fragment crystallizable (FC) region and antigenbinding fragment (Fab) (19), our junction library enables precise control over the orientation of the fused dom”