Fat and beyond: the diverse biology of PPARgamma.
By P. Tontonoz, B. Spiegelman. Annual Review of Biochemistry, 2008
2,131 citations recorded by the source corpus.
Subfields: Epidemiology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/660240a23972a91d9147b50fa7d9ddedba152124
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
- Christopher D. Byrne
- G. Targher
- Herbert Tilg
- André Tchernof
- J. Despres
- W. Kim
- Jerrold M. Olefsky
- M. Trauner
In Molecular Biology
- Navdeep S. Chandel
- Elena Ansó
- R. Hamanaka
- Amanda Birmingham
- Christopher D. Byrne
- Jerrold M. Olefsky
- B. Kalyanaraman
- K. Tormos
In Physiology
- R. Zechner
- R. Zimmermann
- J. Despres
- Christopher D. Byrne
- W. Kim
- Jerrold M. Olefsky
- André Tchernof
- Dorothy Moseti
Citations in the corpus
- Structure-based prediction of protein-protein interactions on a genome-wide scale (2012, neutral): “cofactors to regulate target gene transcription [7].”
- Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. (2017, positive): “Given the obvious importance of PPARg for adipocyte function and systemic metabolism (Sugii et al., 2009; Tontonoz et al., 1994; Tontonoz and Spiegelman, 2008), we conducted further studies in miR-155KO mice and bone marrow transplant chimeras.”
- Mitochondrial complex III ROS regulate adipocyte differentiation (2011, positive): “The transcription factors PPARg and C/EBPa drive white adipocyte differentiation, while the transcriptional regulators PRDM16 and PPARg drive brown fat differentiation (Tontonoz and Spiegelman, 2008).”
- ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1 (2011, background): “PPAR-γ is more common in cells involved in fat storage, and it induces the expression of lipogenic gene”
- Metabolism Disrupting Chemicals and Metabolic Disorders (2016, neutral): “and -δ [123, 124] which establish a sustained feedback loop.”
- NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications (2020, positive): “110 PPARs are a group of nuclear receptor proteins that function as transcription regulators and PPAR-γ heterodimerises with retinoid X receptor and binds to specific DNA sequences to regulate adipocyte differentiation and function, lipid metabolism and inflammation.”
- Reprogramming of the Circadian Clock by Nutritional Challenge (2013, neutral): “PPARγ is a nuclear receptor involved in glucose and lipid metabolism (Fajas et al., 2001; Perreault et al., 2010) and has been described as a nutrient sensor in metabolic tissues (Spiegelman, 1998; Tontonoz and Spiegelman, 2008).”
- Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “These drugs regulate lipid and glucose metabolism and suppress inflammatory responses by macrophages and microglia (Tontonoz and Spiegelman, 2008).”