Pulmonary hypertension due to left heart diseases.
By J. Vachiéry, Y. Adir, J. Barberà, H. Champion, J. Coghlan, V. Cottin, T. De Marco, N. Galiè, S. Ghio, J. Gibbs and 5 more. Journal of the American College of Cardiology, 2013
608 citations recorded by the source corpus.
Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH has been used to identify that population without a clear definition, which has been found less than ideal and created confusion. We propose a change in terminology and a new definition of PH due to LHD. We suggest to abandon "out-of-proportion" PH and to distinguish "isolated post-capillary PH" from "post-capillary PH with a pre-capillary component" on the basis of the pressure difference between diastolic pulmonary artery pressure and pulmonary artery wedge pressure. Although there is no validated treatment for PH-LHD, we provide insights into management and discuss completed and randomized trials in this condition. Finally, we provide recommendations for future clinical trials to establish safety and efficacy of novel compounds to target this area of unmet medical need.
Subfields: Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/6574f00effcde7647f27deeeb58514ba8c937967
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In Cardiology and Cardiovascular Medicine
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Left ventricular heart failure and pulmonary hypertension (2015, methodology): “Despite recent advances in the pathophysiological understanding and clinical assessment, and adjustments in the haemodynamic definitions and classification of PH-LHD, the haemodynamic interrelations in combined post- and pre-capillary PH are complex, definitions and prognostic significance of haemod”
- Updated clinical classification of pulmonary hypertension. (2009, background): “An update for Groups 2, 3, and 4 will be published separately in the same issue of this supplement (66 – 68), providing some important adaptations regarding de fi nitions and management.”