Toxicity of lead: A review with recent updates
By G. Flora, D. Gupta, Archana Tiwari. Interdisciplinary Toxicology, 2012
1,999 citations recorded by the source corpus.
Abstract Lead poisoning has been recognized as a major public health risk, particularly in developing countries. Though various occupational and public health measures have been undertaken in order to control lead exposure, cases of lead poisoning are still reported. Exposure to lead produces various deleterious effects on the hematopoietic, renal, reproductive and central nervous system, mainly through increased oxidative stress. These alterations play a prominent role in disease manifestations. Modulation of cellular thiols for protection against reactive oxygen species (ROS) has been used as a therapeutic strategy against lead poisoning. N-acetylcysteine, α-lipoic acid, vitamin E, quercetin and a few herbal extracts show prophylaxis against the majority of lead mediated injury in both invitro and in vivo studies. This review provides a comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity. It also updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations.
Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/65282c94234cbd12f6d5f560934931cd0171210c
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In Health, Toxicology and Mutagenesis
In Nutrition and Dietetics
Citations in the corpus
- Lead toxicity: a review (2015, methodology): “A new technique called nano-encapsulation of antioxidants may provide improved biodistribution and bioavailability of poorly soluble therapeutics through solubilisation (Flora et al., 2012).”
- Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “It has an ability to mimic and replace essential cations such as Ca2+ and Mg2+, which are involved in various biological processes including cell adhesion, intraand inter-cellular signalling, apoptosis, ionic transportation, protein folding, enzyme regulation, and release of neurotransmitters [128,1”
- Bacterial Exopolysaccharide mediated heavy metal removal: A Review on biosynthesis, mechanism and remediation strategies (2016, background): “Exposure at about 400–600 mg/L can also lead to chronic toxicity which is characterized by persistent vomiting, encephalopathy, lethargy, delirium, convulsions and coma if not attended timely [22].”