Nuclear receptors and lipid physiology: opening the X-files.

By A. Chawla, J. Repa, R. M. Evans, D. Mangelsdorf. Science, 2001

2,138 citations recorded by the source corpus.

Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed by the intestine and transformed by metabolic enzymes before they are delivered to their sites of action in the body. Ultimately, the lipids must be eliminated to maintain a normal physiological state. The need to coordinate this entire lipid-based metabolic signaling cascade raises important questions regarding the mechanisms that govern these pathways. Specifically, what is the nature of communication between these bioactive lipids and their receptors, binding proteins, transporters, and metabolizing enzymes that links them physiologically and speaks to a higher level of metabolic control? Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.

Subfields: Cancer Research, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/64f814ad0aeac192b62ba73440505b91b0fde6aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Y. Kawano
2. D. Cohen
3. A. Chawla
4. M. Laplante
5. David M. Sabatini

In Molecular Biology

1. Sepp Hochreiter
2. Thomas Unterthiner
3. Günter Klambauer
4. D. Cohen
5. Y. Kawano
6. Tiangang Li
7. J. Y. Chiang
8. S. Kersten

In Surgery

1. J. Y. Chiang
2. D. Cohen
3. Y. Kawano
4. Tiangang Li
5. S. Kersten
6. Bart Staels
7. D. Mangelsdorf
8. C. Stanton

Citations in the corpus

• Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. (2008, background): “PPARs, members of the nuclear receptor superfamily (Chawla et al., 2001), control systemic fatty acid metabolism by transcriptional activation of target genes (Evans et al.”
• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “LXRa and PPARg sense the fed state by responding to dietary cholesterol and fat, promoting the effects of insulin, and facilitating the storage of fat as a fuel source (Chawla et al., 2001; Evans et al., 2004; Kalaany et al., 2005).”