Ferroptosis: mechanisms, biology and role in disease
By Xuejun Jiang, Brent R. Stockwell, M. Conrad. Nature reviews. Molecular cell biology, 2021
6,478 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/64d5f8a482f4e0ebb6daeb342be525b753ab4e77
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Molecular Biology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Ferroptosis in infection, inflammation, and immunity (2021, background): “Ferroptosis in infectious, inflammatory, and immune diseases Accumulating preclinical data suggest the involvement of ferroptosis-relevant regulators and pathways in human disorders (Jiang et al., 2021a; Stockwell et al., 2020; Tang et al., 2021).”
- Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “11 The process of ferroptosis involves ferrous iron accumulation, free radical production, antioxidant system dysfunction, and lipid peroxidation.”
- NLRP3 inflammasome activation and cell death (2021, background): “Cellular FADD-like IL-1β-converting enzyme-inhibitory protein (c-FLIP) is a major antiapoptotic regulator that suppresses the activation of caspase-8 and -10, thereby preventing the initiation of downstream apoptotic cascades [123].”
- Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. (2022, neutral): “, 2010) whereas these features are not observed in ferroptosis (Jiang et al., 2021).”
- Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones (2023, background): “Multiple surveillance mechanisms have evolved to suppress cellular PL peroxidation and subsequent ferroptosis, making these mechanisms pivotal points for ferroptosis regulation.(1,2) GPX4 and various RTA-generating enzymes mediate two well-characterized surveillance mechanisms.”
- Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Further studies have shown that ferroptosis and oxytosis share several molecular features and pathways.(190,268) For example, oxidative stress and GSH depletion are typical features of both oxytosis and ferroptosis.”