An Arabidopsis Gene Regulatory Network for Secondary Cell Wall Synthesis
By Mallorie Taylor-Teeples, Li Lin, M. Lucas, G. Turco, Ted W. Toal, Allison Gaudinier, N. Young, Gina M. Trabucco, Mike T. Veling, R. Lamothe and 17 more. Nature, 2014
683 citations recorded by the source corpus.
The plant cell wall is an important factor for determining cell shape, function and response to the environment. Secondary cell walls, such as those found in xylem, are composed of cellulose, hemicelluloses and lignin and account for the bulk of plant biomass. The coordination between transcriptional regulation of synthesis for each polymer is complex and vital to cell function. A regulatory hierarchy of developmental switches has been proposed, although the full complement of regulators remains unknown. Here we present a protein–DNA network between Arabidopsis thaliana transcription factors and secondary cell wall metabolic genes with gene expression regulated by a series of feed-forward loops. This model allowed us to develop and validate new hypotheses about secondary wall gene regulation under abiotic stress. Distinct stresses are able to perturb targeted genes to potentially promote functional adaptation. These interactions will serve as a foundation for understanding the regulation of a complex, integral plant component.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/64ba86a9f6fd5a06518eb357b02ba5a55a496024
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
In Plant Science
Citations in the corpus
- Lignocellulosic biomass: Biosynthesis, degradation, and industrial utilization (2016, background): “thaliana generated a consistent model predicting gene perturbation at the tissue level induced by several stresses (pH stress, sulfur, and iron derivation, salt stress) and nitrogen influx [110].”
- PlantRegMap: charting functional regulatory maps in plants (2019, background): “Systematic identification of TFs, regulatory elements and functional interactions between them would greatly facilitate further mechanistic investigation (1,2).”