The leucine-rich repeat: a versatile binding motif.

By Bostjan Kobe, J. Deisenhofer. 1994

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Citations in the corpus

Hallucinating symmetric protein assemblies (2022, background): “While the α/β topology of some of these larger HALs is reminiscent of natural Leucine Rich Repeats (LRRs, (34)), which is reflected by a median highest protomer TM-scores of 0.”
Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. (2000, background): “found in a diverse group of proteins (13, 14).”
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. (2007, background): “These domains are conserved features among most extracellular LRR proteins (Kobe and Deisenhofer, 1994).”
Protein repeats: structures, functions, and evolution. (2001, background): “Leucine-rich repeats (Kobe and Deisenhofer, 1994) (LRRs) are relatively short in comparison to other repeat families, with lengths of about 20 amino acids.”
The lutropin/choriogonadotropin receptor, a 2002 perspective. (2002, background): “Tandem arrays of LRRs have been found in many proteins including hormone receptors and other hormone binding proteins, cell adhesion and extracellular matrix proteins, enzymes, and enzyme inhibitors (42, 43).”
Plant NBS-LRR proteins in pathogen sensing and host defense (2006, background): “Several LRR domains from non-plant proteins have been crystallized; they form barrel-like structures with a parallel β-sheet lining the inner concave surface and α-helical structures comprising much of the rest of the domai”
A receptor kinase gene regulating symbiotic nodule development (2002, background): “2a , the predicted proteins possess an amino-terminal signal peptide motif, a putative extracellular domain containing three leucine-rich repeat (LRR) motif”
MAX1 and MAX2 control shoot lateral branching in Arabidopsis. (2002, background): “MAX2 deviates from a perfect LRR structure (Kobe and Deisenhofer, 1994), as the distance between the repeats varies.”
Plant Receptor-Like Kinase Gene Family: Diversity, Function, and Signaling (2001, background): “Downstream of the multiprotein signaling complex, two genes, WUSCHEL (16, 90) and POLTERGEIST (91), are negatively regulated by CLAVATA1.”
Dental adhesion review: aging and stability of the bonded interface. (2008, background): “In other words proteoglycansmay be responsible of the three-dimensional appearance of the dentin organic matrix due to their ability to fill space, bind and organize water molecules, and repel negatively charged molecules [72–76].”
Hallucinating protein assemblies (2022, background): “While the α/β topology of some of these larger HALs is reminiscent of natural Leucine Rich Repeats (LRRs, ( 31 )), which is reflected by a median highest protomer TM-scores of 0.64, these ring-shaped structures differ considerably from the horseshoe folds of LRRs that do not close into cyclic…”