The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties.

By S. Ryter, R. Tyrrell. Free Radical Biology & Medicine, 2000

850 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/64a6d1d3f1918d1fc3b982445909e1fb3e540a4b

How researchers see this paper

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In Cell Biology

1. Kostas Pantopoulos

In Molecular Biology

1. Rui Wang
2. Lingyun Wu
3. Kostas Pantopoulos
4. A. Kappas
5. Nader G. Abraham

In Pediatrics, Perinatology and Child Health

1. Rui Wang
2. Kostas Pantopoulos
3. A. Kappas
4. Nader G. Abraham

Citations in the corpus

• Iron metabolism and toxicity. (2005, background): “Interestingly, heme iron (either bfreeQ or within hemoproteins) may also catalyze the formation of radicals, mainly via formation of oxoferryl intermediates (Ryter and Tyrrell, 2000) (Fig.”
• Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications (2005, background): “Normal cellular functions would be disturbed and pathological cellular injuries exacerbated (Dennery et al., 1998; Ryter and Tyrrell, 2000).”
• Oxidative stress in the pathogenesis of skin disease. (2006, background): “In addition, heme pathway intermediates may have prooxidant effects, whereas heme oxyge- nase, an enzyme that degrades heme, can function as both an antioxidant and a pro-oxidant (Ryter and Tyrrell, 2000).”