Serine and glycine metabolism in cancer
By I. Amelio, F. Cutruzzolà, A. Antonov, M. Agostini, G. Melino. TIBS -Trends in Biochemical Sciences. Regular ed, 2014
967 citations recorded by the source corpus.
Highlights • Serine and glycine are essential metabolites for cancer cells.• Serine and glycine provide precursors for macromolecules and antioxidant defence.• Metabolic enzymes of serine and glycine biosynthesis are upregulated in cancer.• Innovative anticancer therapy is aiming to target serine and glycine biosynthesis.
Subfields: Biochemistry, Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/646e4b5586f440eeaad728866ae9575008149ace
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In Biochemistry
In Cancer Research
In Molecular Biology
Citations in the corpus
- ROS homeostasis and metabolism: a dangerous liason in cancer cells (2016, background): “More recent evidence indicates that this pathway is also crucial for redox balance.(115,116) With this respect, the mitochondria have been shown to have a prominent role.”
- One-Carbon Metabolism in Health and Disease. (2017, background): “Serine Synthesis and Mitochondrial Folate Genes Are Overexpressed in Cancer New genomics and metabolomics approaches have highlighted distinctive aspects of 1C metabolism in cancer and rekindled interest in targeting this pathway with more selective antifolates (Amelio et al., 2014; Locasale, 2013).”
- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “So far, several drugs targeting enzymes that catalyze the generation of tetrahydrofolate involved in one-carbon metabolism, including methotrexate and Pemetrexed against dihydrofolate reductase, have been clinically approved in multiple cancers [67].”