From the Cover: PNAS Plus: Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans

By Jeffrey P. Nguyen, Frederick B. Shipley, Ashley N. Linder, George S. Plummer, Mochi Liu, S. Setru, Joshua W. Shaevitz, Andrew M Leifer. 2016

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Computational neuroethology: a call to action (2019, background): “…neurons in the brains of the worm C. elegans and the zebrafish D. Rerio can be recorded simultaneously, thereby allowing a large fraction of the brain’s neural dynamics to be observed (Cong et al., 2017; Kim et al., 2017; Nguyen et al., 2016; Symvoulidis et al., 2017; Venkatachalam et al., 2016).”
BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples (2018, methodology): “elegans dauer larvae expressing tagRFP fused to a nuclear localizing sequence under the pan-neuronal rab-3 promotor in all neuron nuclei [29] were obtained by selecting dauer larvae in 1% SDS for 30 minutes [30].”
Towards the neural population doctrine. (2019, background): “In fact, the recorded behavior may be high-dimensional enough that one may need to use population analysis to characterize the behavior in the ﬁrst place, then relate neural activity to this complex behavior [73–75]. ii) Discovering causal relationships to behavior .”