Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial

By Timothy J. Brennan, Jean Mantz. 2010

1,378 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Developmental Neuroscience, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/63e2b4fcf443f6757566d7e5aed5ca28fb87389c

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In Critical Care and Intensive Care Medicine

In Developmental Neuroscience

In Pulmonary and Respiratory Medicine

Citations in the corpus

Chronic critical illness. (2010, background): “Integration of physical therapy in a comprehensive rehabilitative model for care is supported by a consensus of expert opinion (2) and by evidence emerging from the setting of acute critical illness, which indicates that early mobilization may mitigate development, severity, and/or duration of post-”
Sedation in the intensive care setting (2012, positive): “Furthermore, combining daily interruption of sedation with physical and occupational therapy has been shown to lead to significant improvement in functional status at hospital discharge.(87)”
The ABCDEF Bundle in Critical Care (2017, background): “Although both these studies demonstrated feasibility of physical therapy, it may be more effective to embark on physical therapy early in the ICU course, rather than later when it is much more challenging to improve ICU-acquired weakness.(65,66) The focus on rehabilitation of critically ill patients”
Long-term complications of critical care (2011, background): “Specifically, a two-site trial demonstrated that mechanically ventilated patients randomized to early occupational and physical therapy starting within 72 hrs of intubation were more likely to return to independent functional status at hospital discharge than patients who received similar rehabilita”
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care (2021, background): “described, and similar interventions are thought to be useful for cardiac arrest patients as well.(437,468) 470 Recommendations in the UK National Institute for Health and Care Excellence (NICE) guidelines for rehabilitation after critical illness suggest that individualised rehabilitation plans and”
Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis (2010, positive): “The literature on intensive care unit–acquired weakness and chronic illness myopathy and polyneuropathy suggests that there is a direct inflammatory and hypoperfusionmediated degradation of muscle fibers and neurons,(35-37) which may be exacerbated by prolonged immobility(38) and lack of physical th”
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit (2013, background): “In the first multicenter randomized controlled trial of early mobility (330), and in a subsequent implementation study (407), investigators also noted striking reductions in the incidence of delirium, depth of sedation, and hospital and ICU LOS, with an increase in ventilator-free days.”
Days of delirium are associated with 1-year mortality in an older intensive care unit population. (2009, background): “Schweickert and colleagues recently demonstrated a reduction in ICU delirium days with a protocol of early mobilization and occupational therapy (38).”
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. (2011, background): “95,96 Early physical and occupational therapy in the ICU improves functional independence of patients, although muscle strength is not greatly improved.”