Role of interleukin-1β during pain and inflammation
By K. Ren, R. Torres. Brain Research Reviews, 2008
701 citations recorded by the source corpus.
The cytokine cascade in pain and inflammatory processes is a tremendously complex system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory cytokine that has been implicated in pain, inflammation and autoimmune conditions. This review will focus on studies that shed light on the critical role of IL-1β in various pain states, including the role of the intracellular complex, the inflammasome, which regulates IL-1β production. Evidence will be presented demonstrating the importance of IL-1β in both the induction of pain and in the maintenance of pain in chronic states, such as after nerve injury. Additionally, the involvement of IL-1β as a key mediator in the interaction between glia and neurons in pain states will be discussed. Taken together, the evidence presented in the current review showing the importance of IL-1β in animal and human pain states, suggests that blockade of IL-1β be considered as a therapeutic opportunity.
Subfields: Dermatology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/63dfc9bb913cefd675df37248603d632620b981c
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Citations in the corpus
- The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Within the CNS IL-1β is expressed at low levels by both neurons and glial cells (Ren and Torres 2009; Clark et al. 2006; Copray et al. 2001; Guo et al. 2007; Sommer and Kress 2004), and the expression of IL-1R1 is equally widespread within the spinal cord (Zhang et al.”