Positive Natural Selection in the Human Lineage

By Pardis C Sabeti, S. Schaffner, B. Fry, J. Lohmueller, P. Varilly, O. Shamovsky, A. Palma, Tarjei S. Mikkelsen, David Altshuler, Eric S. Lander. Science, 2006

1,133 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/63ddb9e5f8d6d2df10f05172fe88a4fe6afdead9

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Citations in the corpus

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. (2016, methodology): “As a result, we examine three methods to deal with LD: data set pruned for LD above a threshold í µí±, one SNP of any pair of SNPs in LD (í µí± 2 > í µí±) is removed from the data.”
Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics (2013, background): “Negative selection is widespread in the genome; nevertheless, some positions within negatively selected regions also experience positive selection (33-36).”
The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation (2010, neutral): “variation around the selected site in ways that can be detected using a variety of tests of selection [5].”
A Comparative Encyclopedia of DNA Elements in the Mouse Genome (2014, background): “…it is not clear how extensive the changes in expression patterns are between more distantly related species, such as mouse and human, with some studies emphasizing similarities in transcriptome patterns of orthologous tissues 39–41 and others emphasizing substantial interspecies differences 42 .”
The road to everywhere : Evolution, complexity and progress in natural and artificial systems (2008, background): “This creates new possibilities for the detection of natural selection, based on direct assessment of nucleotide variation (Sabeti and colleagues [157] provide a recent review.”
Genome-wide detection and characterization of positive selection in human populations (2007, background): “1): (1) selected alleles detectable by our tests are likely to be derived (newly arisen), because long-haplotype tests have little power to detect selection on standing (pre-existing) variation(14); we therefore focused on derived alleles, as identified by comparison to primate outgroups; (2) select”
Natural selection on genes that underlie human disease susceptibility. (2008, background): “[20], there appears to be an enrichment for targets of selection among genes associated with complex-disease risk relative to Mendelian-disease genes: 8.”