Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications.

By R. Esfand, D. Tomalia. Drug Discovery Today, 2001

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Dendrimers in gene delivery. (2005, background): “The PAMAM dendrimers are normally based on an ethylenediamine or ammonia core with four and three branching points, respectively [149].”
Hyperbranched polymers: from synthesis to applications (2004, background): “A number of excellent reviews have been published on dendrimers, linear-dendritic hybrids, and dendronized polymers, covering synthesis, functionalization, supramolecularself-assemblyandapplications [1–34].”
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review (2018, background): “The dendritic structures that have been thoroughly investigated and received widespread focus are Tomalia’s poly (amidoamine) (PAMAM) [84,85] and Newcome’s ‘arboreal system’ [86,87].”
Poly(amidoamine), polypropylenimine, and related dendrimers and dendrons possessing different 1 → 2 branching motifs : An overview of the divergent procedures (2008, background): “5 PAMAMs e to their 1 / 3 C-branched, surface-polyhydroxy derivatives in order to study their potential for drug delivery [699,700]; in essence, transforming the PAMAM dendrimers to arborols [23].”