Viral Quasispecies Evolution

By E. Domingo, J. Sheldon, C. Perales. Microbiology and Molecular Reviews, 2012

937 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum (2021, neutral): “Many thousands of mutational changes have been described across the viral genome, and althoughmost will be detrimental or confer no advantage to the virus, somewill be advantageous and be the subject of rapid natural selection (Domingo et al., 2012; Rambaut et al., 2020).”
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization (2021, background): “We did not directly address the fitness of the mutants generated in this study, and any studies of the fitness of the VSVSARS-CoV-2 variants would pertain to their relative replicative fitness measured in cell culture (Domingo et al., 2012).”