The multifaceted role of chromosomal instability in cancer and its microenvironment
By S. Bakhoum, Lewis C. Cantley. Cell, 2018
615 citations recorded by the source corpus.
Chromosomal instability (CIN) is a hallmark of human cancer and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment in the course of immune editing and evasion.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6322c84c0fee0b91087ddc30227c7d9b2d142d23
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In Immunology
In Molecular Biology
Citations in the corpus
- Intratumor heterogeneity: the Rosetta stone of therapy resistance (2020, background): “On the other hand, chromosomal instability has been linked to the induction of inflammatory signaling through cGAS-STING anti-viral pathway (Bakhoum and Cantley, 2018), thus modulating microenvironments, including immune responses.”