The Immunological Genome Project: networks of gene expression in immune cells

By T. Heng, Michio W. Painter, Kutlu G. Elpek, Veronika Lukacs-Kornek, Nora Mauermann, S. Turley, Daphne Koller, Francis Kim, A. J. Wagers, Natasha Asinovski and 28 more. Nature Immunology, 2008

1,839 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/62eeb6f2cf61abf2a1b11fb5c2372e5889ccaa00

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In Immunology

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Citations in the corpus

• Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species (2019, methodology): “For mouse, we used a comparable data set from the IMMGEN consortium (Heng et al., 2008).”
• Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses (2014, neutral): “0ST platform, with ImmGen protocols (Heng and Painter, 2008).”
• Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. (2012, methodology): “Microarray data sets for other cells were obtained from data assembled by the ImmGen consortium (Heng and Painter, 2008).”
• Parsing the interferon transcriptional network and its disease associations (2016, positive): “0 microarrays according to ImmGen SOP (Heng et al., 2008).”
• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014, background): “Although much progress has been made in the understanding of macrophage activation, polarization, and function, the transcriptional programs regulating these processes remain poorly characterized.”
• The molecular anatomy of mouse skin during hair growth and rest (2019, background): “…dendritic cells (DC) marked by Cd209a and Cd74, Langerhans cells (LC) marked by Cd207 and Mfeg8, and three subpopulations of macrophages (MC) characterized by, for example, Ccl6, C1qa and Cd209f (MC1), Ccl6 and Lyz1 (MC2), and Ccl6, Ly6c2 and Emilin2 (MC3) (Heng et al., 2008) (Figures 6B and S7M).”
• A neurodegeneration-specific gene expression signature and immune profile of acutely isolated microglia from an ALS mouse model (2013, neutral): “These results may reflect the multifaceted role of microglia in ALS (Henkel et al., 2009).”
• Wishbone identifies bifurcating developmental trajectories from single-cell data (2016, result): “We next compared the mean gene expression of markers in ImmGen sorted populations [16] to Wishbone marker dynamics and note discrepancies between the datasets.”
• Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages (2012, background): “Likewise, the transcription factor Batf3, which is required for the development of the CD8+ cDC lineage, is expressed in cDCs but also in other myeloid cells (Heng and Painter, 2008) and differentiated TH1 cells (Hildner et al., 2008).”