Community-Acquired Klebsiella pneumoniae Bacteremia: Global Differences in Clinical Patterns

By W. Ko, David L. Paterson, Anthanasia J. Sagnimeni, D. S. Hansen, A. von Gottberg, Sunita Mohapatra, J. Casellas, H. Goossens, L. Mulazımoglu, G. Trenholme and 3 more. Emerging Infectious Diseases, 2002

596 citations recorded by the source corpus.

We initiated a worldwide collaborative study, including 455 episodes of bacteremia, to elucidate the clinical patterns of Klebsiella pneumoniae. Historically, community-acquired pneumonia has been consistently associated with K. pneumoniae. Only four cases of community-acquired bacteremic K. pneumoniae pneumonia were seen in the 2-year study period in the United States, Argentina, Europe, or Australia; none were in alcoholics. In contrast, 53 cases of bacteremic K. pneumoniae pneumonia were observed in South Africa and Taiwan, where an association with alcoholism persisted (p=0.007). Twenty-five cases of a distinctive syndrome consisting of K. pneumoniae bacteremia in conjunction with community-acquired liver abscess, meningitis, or endophthalmitis were observed. A distinctive form of K. pneumoniae infection, often causing liver abscess, was identified, almost exclusively in Taiwan.

Subfields: Epidemiology, Microbiology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/62e81ad3d388ea5d041fd7ec1b7461f2d75d1500

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In Molecular Medicine

1. J. Mecsas
2. M. Paczosa

Citations in the corpus

• A Novel Virulence Gene in Klebsiella pneumoniae Strains Causing Primary Liver Abscess and Septic Metastatic Complications (2004, background): “In the past 15 yr, a new type of invasive K. pneumoniae disease has emerged in Taiwan (4‐10) that typically presents a community-acquired primary liver abscess with sepsis and bacteremia ( 4 , 5). Metastatic meningitis or endophthalmitis complicated the course in 10‐12% of cases (6‐9).”
• Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. (2004, unknown): “pneumoniae bacteremia ever performed [8, 9].”
• Klebsiella pneumoniae: Going on the Offense with a Strong Defense (2016, background): “pneumoniae as the etiological agent of CAPs in Asia and Africa is likely due, at least in part, to the increased prevalence of hypervirulent strains in these areas (42).”
• Hypervirulent (hypermucoviscous) Klebsiella pneumoniae (2013, background): “Although some patients with hvKP appear to present with aspiration-mediated pneumonia,(43) the primary site of infection is most often outside of the lungs.(4,42) Given the common presentation of pyogenic liver abscess (PLA), the ability to invade across an intact intestinal mucosa, which occurs wit”
• Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae (2018, unknown): “(Wang et al., 1998; Ko et al., 2002; Liu et al., 2014).”