Regulatory T cells

By Shimon Sakaguchi. Springer Seminars in Immunopathology, 2006

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Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China (2020, background): “It has been shown that T cells, especially CD4+ and CD8+ T cells, play an important role in weakening or dampening overactive innate immune responses during viral infection [17], although regulatory T cells, a subset of Th cells, play a crucial role in negatively regulating the activation, prolifera”
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation (2005, background): “CD4 CD25 regulatory T cells (T reg cells) were initially defined as a subpopulation of suppressor T cells that mediate immune tolerance by suppressing autoreactive T cells (1, 2).”