Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment

By Z. Ismail, Eric E. Smith, Y. Geda, D. Sultzer, Henry Brodaty, Gwenn S. Smith, L. Agüera-Ortiz, R. Sweet, David S. Miller, C. Lyketsos. Alzheimer's & Dementia, 2015

741 citations recorded by the source corpus.

Neuropsychiatric symptoms (NPS) are common in dementia and in predementia syndromes such as mild cognitive impairment (MCI). NPS in MCI confer a greater risk for conversion to dementia in comparison to MCI patients without NPS. NPS in older adults with normal cognition also confers a greater risk of cognitive decline in comparison to older adults without NPS. Mild behavioral impairment (MBI) has been proposed as a diagnostic construct aimed to identify patients with an increased risk of developing dementia, but who may or may not have cognitive symptoms. We propose criteria that include MCI in the MBI framework, in contrast to prior definitions of MBI. Although MBI and MCI can co‐occur, we suggest that they are different and that both portend a higher risk of dementia. These MBI criteria extend the previous literature in this area and will serve as a template for validation of the MBI construct from epidemiologic, neurobiological, treatment, and prevention perspectives.

Subfields: Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/6286c11930559fd2b7450e60ce6d709631f3149a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. William J. Jagust
2. Clifford R. Jack Jr.
3. C. Teunissen
4. José Luis Molinuevo

In Psychiatry and Mental health

1. William J. Jagust
2. Clifford R. Jack Jr.
3. José Luis Molinuevo

Citations in the corpus

• NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease (2018, neutral): “, depression, anxiety, and apathy) rather than cognitive [189].”
• Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup (2024, positive): “All three of these components can be attributable to AD, but they also can be attributable to factors other than AD, particularly neurobehavioral symptoms (e.g., depression, anxiety, apathy), 155–157 which are often not associated with neurodegenerative disease.”
• Diagnosis of Early Alzheimer's Disease: Clinical Practice in 2021 (2021, neutral): “In the early stages of disease, such symptoms are generally associated with poor long-term outcomes and caregiver burden, and are particularly distressing to both patients and their families (63).”