Cation-chloride cotransporters in neuronal development, plasticity and disease

By Kai Kaila, Theodore John Price, J. A. Payne, Martin Puskarjov, J. Voipio. Nature Reviews Neuroscience, 2014

681 citations recorded by the source corpus.

Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy. In recent years, it has become evident that one family of ion transporters, cation-chloride cotransporters (CCCs), and in particular K+–Cl− cotransporter 2 (KCC2), have seminal roles in shaping GABAergic signalling and neuronal connectivity. Studying the functions of these transporters may lead to major paradigm shifts in our understanding of the mechanisms underlying brain development and plasticity in health and disease.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/626a777e414368c4c21d06b725c6624dd87709e5

Citations in the corpus

• Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, neutral): “increase HCO3 permeability and, thus, depolarization (Staley et al., 1995; Kaila et al. 2014).”