Structure of a Ribonucleic Acid

By R. W. Holley, J. Apgar, G. Everett, J. T. Madison, M. Marquisee, S. H. Merrill, J. Penswick, A. Zamir. 1965

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Assessment of three-dimensional RNA structure prediction in CASP15 (2023, positive): “We selected the following tools for our ranking schemes: (1) US-align(28), which was used to compute TM-score through a heuristic alignment approach improving on the original RNA-align(26); (2) Local-Global Alignment(29) which yielded GDT-TS, the average percentage of aligned C4’ atoms (rather than ”
Recent advances in RNA structurome (2022, background): “In 1965, Robert Holley and his collaborators published the nucleotide sequence of yeast alanine transfer RNA (tRNA) and proposed its possible secondary structure (Holley et al., 1965).”
RNAcentral 2021: secondary structure integration, improved sequence search and new member databases (2020, background): “In addition, there are accepted layouts and orientations for the display of secondary structures of well-known families (such as rRNA and tRNA) (8,9), but existing automated 2D visualization tools do not account for these layouts, making it difficult to analyze and compare structured RNAs.”
An RNA-centric historical narrative around the Protein Data Bank (2021, background): “Its primary and secondary structures had been determined in the 1960s, by chemical and biochemical means (37, 38).”
Next-Generation Sequencing Technology: Current Trends and Advancements (2023, methodology): “Robert Holley was the ﬁrst to sequence a nucleic acid molecule, Alanine tRNA, in 1964 using ribonuclease from S. cerevisiae [11].”