Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

By M. Kosicki, Kärt Tomberg, Allan Bradley. Nature Biotechnology, 2018

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CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future (2020, background): “In addition, large deletions spanning kilobases and complex rearrangements as unintended consequences of on-target activity have been reported in several instances (71, 72), highlighting a major safety issue for clinical applications of DSB-inducing CRISPR therapy.”
CRISPR-engineered T cells in patients with refractory cancer (2020, background): “In addition to the above detection of repair of double-strandDNAbreaks byNHEJ, on-target mutagenesis by engineered nucleases can result in deletions, duplications, inversions, and translocations and can also lead to complex chromosomal rearrangements under some conditions (37).”
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects (2020, background): “Targeted DNA alterations begin from the generation of nuclease-induced double-stranded breaks (DSBs), which leads to the stimulation of highly efficient recombination mechanisms of cellular DNA in mammalian cells.(5,6) Nuclease-induced DNA DSBs can be repaired by one of the two major mechanisms that”