EGF receptor trafficking: consequences for signaling and cancer

By Alejandra Tomas, C. Futter, Emily R. Eden. Trends in Cell Biology, 2014

747 citations recorded by the source corpus.

Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival.• Signaling from activated EGFR occurs at the endosome as well as the cell surface.• Endocytosis can have positive and negative effects on signaling and tumorigenesis.• EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.

Subfields: Molecular Biology, Oncology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/23ac5bb4ad9cc3891f71b49b182343e778998aa4

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In Molecular Biology

1. Ping Wee
2. Zhixiang Wang

In Oncology

1. Ping Wee
2. Zhixiang Wang

Citations in the corpus

• Emerging functions of the EGFR in cancer (2017, background): “For instance, UV radiation, cisplatin, inflammatory cytokines (tumor necrosis factor a), and the antibiotic anisomycin all trigger p38-MAPK activation, required for ligand-independent EGFR internalization (reviewed in Tan et al., 2016a; Tomas et al., 2014).”
• Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “ERBB3 does not contain a kinase domain, therefore ERBB3 homodimers possess little autophosphorylation activity, albeit some is present [27].”