MITF: master regulator of melanocyte development and melanoma oncogene.

By Carmit Levy, M. Khaled, D. Fisher. Trends in Molecular Medicine, 2006

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An Integrated Approach to Uncover Drivers of Cancer (2010, background): “MITF is a master regulator of melanocyte development, function, and survival (Levy et al., 2006; Steingrı´msson et al., 2004), and the overexpression of MITF is known to have an adverse effect on patient survival (Garraway et al., 2005).”
UV Radiation and the Skin (2013, background): “cAMP signaling leads to activation of the protein kinase A (PKA) cascade which, in turn, leads to increased levels and/or activity of many melanogenic enzymes to enhance production and export of melanin by melanocytes [90,196,197] (Figure 4).”
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis (2012, methodology): “1I), the MITF-M isoform, which is predominantly present in melanocytes and naturally has a truncated N terminus due to alternative promoter usage (35) (fig.”
Signaling Pathways in Melanogenesis (2016, background): “MITF binds to specific sequences that are classifiable as members of the widely distributed E-(enhancer)-box family of regulatory motifs [52].”
Melanocyte biology and skin pigmentation (2007, background): “CREB, in turn, transcriptionally activates various genes, including that encoding microphthalmia transcription factor ( MITF ), the transcription factor that is pivotal to the expression of numerous pigment enzymes and differentiation factor”