Targeting immunosuppressive adenosine in cancer

By Dipti Vijayan, A. Young, M. Teng, M. Smyth. Nature Reviews. Cancer, 2017

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Next generation of immune checkpoint therapy in cancer: new developments and challenges (2018, background): “However, an area of concern with this approach is the blockade of adenosine synthetic enzymes which may favor the accumulation of ATP, a molecule that can play a pro-tumor role in the tumor microenvironment [44].”