The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

By M. Kunizaki, Ryuji Hamamoto, F. P. Silva, K. Yamaguchi, T. Nagayasu, M. Shibuya, Yusuke Nakamura, Yoichi Furukawa. 2007

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Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization (2017, background): “the possible functions of methylation on these proteins were discussed [16, 17].”
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B (2012, unknown): “IB: HA (AURKB) HA–AURKB – – + – + – FLAG–AURKB-[1-200] FLAG–AURKB-[201-344]”
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells (2015, methodology): “In vitro methyltransferase assays were performed as described previously [7, 44-50].”
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1 (2016, unknown): “In addition to histone proteins, SMYD3 methylates Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) and Mitogen Activated Protein Kinase 2 (MAP3K2) [15, 16].”
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway (2010, background): “We previously reported that SMYD3, a histone methyltransferase, stimulates cell proliferation through its methyltransferase activity and plays a crucial role in human carcinogenesis [6-10].”