Cucurbiturils: from synthesis to high-affinity binding and catalysis.
By Khaleel I. Assaf, W. Nau. Chemical Society Reviews, 2015
888 citations recorded by the source corpus.
In the wide area of supramolecular chemistry, cucurbit[n]urils (CBn) present themselves as a young family of molecular containers, able to form stable complexes with various guests, including drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocarbons, and even high molecular weight guests such as proteins (e.g., human insulin). Since the discovery of the first CBn, CB6, the field has seen tremendous growth with respect to the synthesis of new homologues and derivatives, the discovery of record binding affinities of guest molecules in their hydrophobic cavity, and associated applications ranging from sensing to drug delivery. In this review, we discuss in detail the fundamental properties of CBn homologues and their cyclic derivatives with a focus on their synthesis and their applications in catalysis.
Subfields: Biomaterials, Organic Chemistry, Physical and Theoretical Chemistry
View Paper: https://www.semanticscholar.org/paper/5fff9633f1790e6ac3368ecdc67fd8a4f33510e6
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In Physical and Theoretical Chemistry
Citations in the corpus
- Predicting binding free energies: Frontiers and benchmarks (2016, background): “Although derivatives of these host molecules have been made [4, 31, 98, 182], most of the binding data published for this class of hosts pertain to the non-derivatized forms.”