Telomere dysfunction in ageing and age-related diseases

By F. Rossiello, D. Jurk, J. Passos, F. d’Adda di Fagagna. Nature Cell Biology, 2022

630 citations recorded by the source corpus.

Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies. Rossiello et al. review the contributions of telomere shortening and/or dysfunction to ageing and a broad spectrum of age-associated human diseases.

Subfields: Aging, Dermatology, Physiology

View Paper: https://www.semanticscholar.org/paper/5f7700d000f5b025619477fe0350208ad1ac3566

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Citations in the corpus

• Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “In COPD patients, the levels of DNA damage markers in lung tissue and peripheral blood cells are increased,(408,409) telomeres are shortened,(387,410) and the expression of DNA repair-related proteins is decreased,(411) all of which are related to disease severity.(412) By regulating the expression ”