Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020

By A. Singanayagam, M. Patel, A. Charlett, J. Lopez Bernal, V. Saliba, J. Ellis, S. Ladhani, M. Zambon, R. Gopal. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2020

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Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.

Subfields: Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/5f610ce149320fe400947f8da15674979ba37f11

Citations in the corpus

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