AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

By Bruce E. Kemp, M. Towler, D. Grahame Hardie. Circulation Research, 2007

1,340 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5f2871f7540e6e61cb2028f9a88b5df398f3daae

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Citations in the corpus

Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction (2017, background): “Activated AMPK downregulates lipogenic genes and activates fat oxidative pathways [99].”
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. (2012, background): “In case of energy shortages, however, the kinase pathways are activated by adenosine monophosphate (AMPK) leading to the inhibition of earlier biosynthetic processes.(64) The IGF1R activation by IGF1 leads to the phosphorylation of tyrosine residues in the intracellular domain of the receptor and ph”
AMPK phosphorylation of raptor mediates a metabolic checkpoint. (2008, background): “In addition, hydrophobic residues including leucine and methionine were strongly selected in the 5 position and the +4 position consistent with previous studies of the optimal peptide substrates for AMPK based on mutagenesis and molecular modeling (Scott et al., 2002; Towler and Hardie, 2007).”
LKB1 and AMPK control of mTOR signalling and growth (2009, background): “The ability of metformin and other AMPK-activating drugs to act as insulin sensitizers is well documented (Towler & Hardie 2007), and one explanation for that effect is that by 70 2009 The Author Journal compilation 2009 Scandinavian Physiological Society, doi: 10.1111/j.1748-1716.2009.01972.x AMPK…”
Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies (2016, background): “122 123 Interestingly, no signi ﬁ cant effect was observed in glucose/ insulin response following LT-HIIT in overweight/obese populations.”
AMP-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype (2008, positive): “However, AICAR is taken up by cells and converted to AMP analogue ZMP which mimics the effect of AMP, thus AICAR is a nonspecific activator of AMPK and has the potential to activate other AMP sensitive enzymes (15).”
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “Thus, under favorable conditions, such as an amino acid-rich diet, when TORC1 is active, phosphorylated S6K functions as a positive mediator of the TOR pathway by promoting C cellular and organismal growth, and additionally by altering metabolism (Montagne et al., 1999; Um et al., 2006).”
New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate (2014, background): “CaMKKβ is an upstream regulator for AMPdependent kinase (AMPK), an energy sensing enzyme that plays crucial roles in energy metabolism and cardiovascular functions [79,94,108].”
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. (2010, background): “To date, close to 20 direct cellular targets of AMPK have been identified (434).”