Directed Evolution: Bringing New Chemistry to Life

By Frances H. Arnold. 2017

959 citations recorded by the source corpus.

Tailor‐made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering. The evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not known in biology, and reactivity inaccessible by small‐molecule catalysts.

Subfields: Molecular Biology, Organic Chemistry

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Kevin Kaichuang Yang
2. Zachary Wu
3. Frances H. Arnold
4. Kadina E. Johnston
5. Zak Costello
6. Héctor García Martín
7. Á. Berenguer-Murcia
8. R. Fernández-Lafuente

In Organic Chemistry

1. Héctor García Martín
2. Zak Costello
3. Frances H. Arnold
4. Kevin Kaichuang Yang
5. Zachary Wu

Citations in the corpus

• How to Hallucinate Functional Proteins (2019, background): “This approach is advantageous because it does not require understanding of the relationship between sequence and function, and can still reach desired performance characteristics in a systematic way (13).”
• Protein sequence design with deep generative models (2021, background): “To improve proteins for human purposes, protein engineers have developed a variety of experimental and computational methods for designing sequences that fold to desired structures or perform desired functions [1, 2, 3, 4].”
• Biotechnological relevance of the lipase A from Candida antarctica (2021, background): “Therefore, directed evolution operates through the generation of a huge number of variant enzymes differing in just one amino acid and submitted to an artificial selection process, that is focused only on the desired featured [32].”