ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking

By S. Soond, B. Everson, D. Riches, Gillian Murphy. 2005

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The ADAM metalloproteinases (2008, background): “Moreover, Soond et al. (2005) have reported that trafficking of ADAM-17 from the endoplasmic reticulum to the cell surface was dependent on Erk phosphorylation at Thr 735.”
TNFα Shedding in Mechanically Stressed Cardiomyocytes is Mediated by Src Activation of TACE (2015, background): “KEY WORDS: CARDIOMYOCYTES; Src; TACE; TNF ; p38 MAPK; MECHANICAL STRETCH The heart adapts to a sustained increase in hemodynamicoverload through a remodeling process that results in cardiac hypertrophy, and eventually leads to left ventricle (LV) dilation and heart failure (Lorell and Carabello, 200”
ADAMs family and relatives in cardiovascular physiology and pathology. (2016, background): “Trafficking of ADAM17 from the endoplasmic reticulum to the cell surface has also been suggested to be dependent on ERK-mediated phosphorylation at Thr735 [42].”
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. (2006, background): “Thr735 and Ser819 have been demonstrated as cytoplasmic phosphorylation (P) sites (24, 93).”