Human ATP-binding cassette (ABC) transporter family
By V. Vasiliou, Konstandinos Vasiliou, D. Nebert. Human Genomics, 2009
735 citations recorded by the source corpus.
There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps. ABC transporters are ubiquitous membrane-bound proteins, present in all prokaryotes, as well as plants, fungi, yeast and animals. These pumps can move substrates in (influx) or out (efflux) of cells. In mammals, ABC transporters are expressed predominantly in the liver, intestine, blood-brain barrier, blood-testis barrier, placenta and kidney. ABC proteins transport a number of endogenous substrates, including inorganic anions, metal ions, peptides, amino acids, sugars and a large number of hydrophobic compounds and metabolites across the plasma membrane, and also across intracellular membranes. The human genome contains 49 ABC genes, arranged in eight subfamilies and named via divergent evolution. That ABC genes are important is underscored by the fact that mutations in at least I I of these genes are already known to cause severe inherited diseases (eg cystic fibrosis and X-linked adrenoleukodystrophy [X-ALD]). ABC transporters also participate in the movement of most drugs and their metabolites across cell surface and cellular organelle membranes; thus, defects in these genes can be important in terms of cancer therapy, pharmacokinetics and innumerable pharmacogenetic disorders.
Subfields: Clinical Biochemistry, Oncology, Surgery
View Paper: https://www.semanticscholar.org/paper/5edc1b9642a6bc75c16311aff3ef2135e7a085fb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Oncology
Citations in the corpus
- Structure and mechanism of ABC transporters (2015, background): “There are 48 ABC transporters in human [8,9] and many of these have been shown to be responsible for or involved in disease states, including cystic fibrosis, Tangier disease, adrenoleukodystrophy, and cancer (see below).”
- Drug resistance and combating drug resistance in cancer (2019, background): “The human genome contains 48 ABC genes and they are classified into seven subfamilies (ABCA-ABCG)[41,42].”
- Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine (2016, background): “ABC transporters often transport drugs and other substances against the concentration gradient using ATP as an energy source [108].”