Lensfree microscopy on a cellphone
By Derek K. Tseng, O. Mudanyali, Cetin Oztoprak, S. Isikman, I. Şencan, O. Yaglidere, Aydogan Ozcan. Lab on a Chip, 2010
476 citations recorded by the source corpus.
We demonstrate lensfree digital microscopy on a cellphone. This compact and light-weight holographic microscope installed on a cellphone does not utilize any lenses, lasers or other bulky optical components and it may offer a cost-effective tool for telemedicine applications to address various global health challenges. Weighing ~38 grams (<1.4 ounces), this lensfree imaging platform can be mechanically attached to the camera unit of a cellphone where the samples are loaded from the side, and are vertically illuminated by a simple light-emitting diode (LED). This incoherent LED light is then scattered from each micro-object to coherently interfere with the background light, creating the lensfree hologram of each object on the detector array of the cellphone. These holographic signatures captured by the cellphone permit reconstruction of microscopic images of the objects through rapid digital processing. We report the performance of this lensfree cellphone microscope by imaging various sized micro-particles, as well as red blood cells, white blood cells, platelets and a waterborne parasite (Giardia lamblia).
Subfields: Atomic and Molecular Physics, and Optics, Biophysics, Media Technology
View Paper: https://www.semanticscholar.org/paper/5eb3c1ef4a3cb2f82fe18919bb4bba53df218b40
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Atomic and Molecular Physics, and Optics
In Media Technology
Citations in the corpus
- Emerging Technologies for Next-Generation Point-of-Care Testing. (2015, unknown): “Two examples are partially coherent lens-free digital in-line holography [25] for imaging blood cells, platelets, and waterborne parasites and fluorescent imaging of single nanoparticles (NPs) and human cytomegaloviruses (Figure 1E) [26].”
- Fluorescent magnetic bead and cell differentiation/counting using a CMOS SPAD matrix (2012, background): “The group of Ozcan recently presented a lensfree microscopy system to image fluorescent and non-fluorescent cells [23] [24] [25].”
- Quantitative Phase Imaging Techniques for the Study of Cell Pathophysiology: From Principles to Applications (2013, background): “In addition, on-chip technique [134] can miniaturize the QPI methodologies, which potentially enables point-of-care diagnosis and treatment of various diseases in a portable and disposable platform.”
- The Smartphone in Medicine: A Review of Current and Potential Use Among Physicians and Students (2012, background): “Engineers have created various microscopes that attach to smartphones, providing a cost-effective and mobile way to bring more technology to poor and rural regions [50-52].”
- Computer-assisted sperm analysis (CASA): capabilities and potential developments. (2014, background): “[58] shows what might be possible starting with a camera phone, if the adapter-provided temperature control and software was enhanced.”