Collective Langevin dynamics of flexible cytoskeletal fibers

By François Nédélec, Dietrich Foethke. 2007

258 citations recorded by the source corpus.

We develop a numerical method to simulate mechanical objects in a viscous medium at a scale where inertia is negligible. Fibers, spheres and other voluminous objects are represented with points. Different types of connections are used to link the points together and in this way create composite mechanical structures. The motion of such structures in a Brownian environment is described by a first-order multivariate Langevin equation. We propose a computationally efficient method to integrate the equation, and illustrate the applicability of the method to cytoskeletal modeling with several examples.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5e8e4b8a37ad92088dd84458301c33a328f23e4d

How researchers see this paper

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In Cell Biology

1. Ting Lu
2. Xiaona Fang
3. Michael J. Shelley
4. Jin Wang
5. Karsten Kruse

In Molecular Biology

1. Ting Lu
2. Xiaona Fang
3. Karsten Kruse
4. Michael J. Shelley
5. Jin Wang

Citations in the corpus

• Nonequilibrium physics in biology (2019, background): “Stochastic simulations aim at accounting for the various constituents individually (Dasanayake and Carlsson, 2013; Nedelec and Foethke, 2007).”
• The Dynamics of Microtubule/Motor-Protein Assemblies in Biology and Physics (2016, methodology): “Cytosim has been used to simulate the self-assembly of MT arrays in fission yeast (see Nédélec & Foethke 2007 for a review), to construct a computational model of the Xenopus meiotic spindle (Loughlin et al. 2010), and recently to investigate the ability of slender spindles to resist compressive loa”