Mitochondrial creatine kinase in human health and disease.
By U. Schlattner, M. Tokarska-Schlattner, T. Wallimann. Biochimica et Biophysica Acta, 2006
637 citations recorded by the source corpus.
Mitochondrial creatine kinase (MtCK), together with cytosolic creatine kinase isoenzymes and the highly diffusible CK reaction product, phosphocreatine, provide a temporal and spatial energy buffer to maintain cellular energy homeostasis. Mitochondrial proteolipid complexes containing MtCK form microcompartments that are involved in channeling energy in form of phosphocreatine rather than ATP into the cytosol. Under situations of compromised cellular energy state, which are often linked to ischemia, oxidative stress and calcium overload, two characteristics of mitochondrial creatine kinase are particularly relevant: its exquisite susceptibility to oxidative modifications and the compensatory up-regulation of its gene expression, in some cases leading to accumulation of crystalline MtCK inclusion bodies in mitochondria that are the clinical hallmarks for mitochondrial cytopathies. Both of these events may either impair or reinforce, respectively, the functions of mitochondrial MtCK complexes in cellular energy supply and protection of mitochondria form the so-called permeability transition leading to apoptosis or necrosis.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5e73e7901a862a5dd5f49da6780db3f141947576
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In Molecular Biology
Citations in the corpus
- Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery (2012, background): “In mitochondria there are two specific forms of mitochondrial CK (Mt-CK): a nonsarcomeric type called ubiquitous Mt-CK expressed in various tissues such as brain, smooth muscle, and sperm, and a sarcomeric Mt-CK expressed in cardiac and skeletal muscle [1].”
- The creatine kinase system and pleiotropic effects of creatine (2011, background): “These dimers rapidly associate into octamers and although this reaction is reversible, octamer formation is strongly favoured by the high mtCK concentration in the inter-membrane space (Schlattner et al. 2006a).”